翻訳と辞書 Words near each other ・ 5-HO-DiPT ・ 5-hour Energy ・ 5-Hour Energy (cycling team) ・ 5-hour Energy 200 ・ 5-Hour Energy 250 ・ 5-hour Energy 301 ・ 5-HT receptor ・ 5-HT1 receptor ・ 5-HT1A receptor ・ 5-HT1B receptor ・ 5-HT1D receptor ・ 5-HT1D receptor agonist ・ 5-HT1E receptor ・ 5-HT1F receptor ・ 5-HT2 receptor ・ 5-HT2A receptor ・ 5-HT2B receptor ・ 5-HT2C receptor ・ 5-HT2c receptor agonist ・ 5-HT3 antagonist ・ 5-HT3 receptor ・ 5-HT4 receptor ・ 5-HT5A receptor ・ 5-HT5B receptor ・ 5-HT6 receptor ・ 5-HT7 receptor ・ 5-HTTLPR ・ 5-Hydroxy-2(5H)-furanone ・ 5-Hydroxycytosine ・ 5-Hydroxyeicosanoid dehydrogenase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク 5-HT2A receptor ： ウィキペディア英語版 5-HT2A receptor The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbitofrontal cortex. This receptor was first given importance as a target of serotonergic psychedelic drugs such as LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones. 5-HT2A may be a necessary receptor for the spread of the human polyoma virus called JC virus. Downregulation of post-synaptic 5-HT2A receptor is an adaptive process provoked by chronic administration of selective serotonin reuptake inhibitors (SSRIs) and classical antipsychotics. Deceased suicidal and otherwise depressed patients have had more 5-HT2A receptors than normal patients. These findings suggest that post-synaptic 5-HT2A overdensity is involved in the pathogenesis of depression. == History == Serotonin receptors were split into two classes by Gaddum and Picarelli when it was discovered that some of the serotonin-induced changes in the gut could be blocked by morphine, whilst the remainder of the response was inhibited by dibenzyline leading to the naming of M and D receptors respectively. 5-HT2A is thought to correspond to what was originally described as D subtype of 5-HT receptors by Gaddum and Picarelli. In the pre-molecular-cloning era when radioligand binding and displacement was the only major tool, spiperone and LSD were shown to label two different serotonin receptors, and neither of them displaced morphine, leading to naming of the 5-HT1, 5-HT2 and 5-HT3 receptors, corresponding to high affinity sites from LSD, spiperone and morphine respectively. Later it was shown that the 5-HT2 was very close to 5-HT1C and thus were clubbed together, renaming the 5-HT2 into 5-HT2A. Thus the 5-HT2 receptor family is composed of three separate molecular entities: the 5-HT2A (formerly known as 5-HT2 or D), the 5-HT2B (formerly known as 5-HT2F) and the 5-HT2C (formerly known as 5-HT1C) receptors. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「5-HT2A receptor」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.